Page 1 of 3 123 LastLast
Results 1 to 10 of 27

Thread: Red Hair Genotype Data (23andMe derived)

  1. #1
    Registered Users
    Posts
    4,743
    Sex
    Y-DNA (P)
    R2a*-M124 (L295-)
    mtDNA (M)
    D4j5*

    Red Hair Genotype Data (23andMe derived)

    Following on from J Man's blonde hair and rms2's Britain's DNA Red Head Test Results threads, it seemed intuitive to extend the discussion into 23andMe's recent report on red hair.

    It is commonly accepted that red hair is largely the result of a mutation on the MC1R gene (please see 23andMe's report for more info). A number of SNPs are encoded within MC1R. I recently revisited S Walsh's DNA Phenotyping: The prediction of human pigmentation traits from genetic data (2013), which presents a compendium of current work on genotype variation with respect to human pigmentation. Within it, 11 SNPs within MC1R are plotted with respect to ancestral (non-red) and derived (red) allele variants across the HGDP reference populations(Figures 3 and 4, attached below). A rough description of these findings for those not logged in can also be found below.

    23andMe's report only lists three SNPs (rs1805007, rs1805008, i3002507), clearly giving it diminished predictive power. Based on the data presented in Walsh's DNA Phenotyping, I've collated those MC1R loci. I don't know which of these SNPs are found in different FTDNA/23andMe chips, so all are listed irrespective.

    Feel free to include yourself in the table by simply quoting the latest post with it and entering the data as appropriate. Have fun folks, hope this makes up for 23andMe's report's inadequacies! (I'm missing 4 SNPs on v2, so I'm non-red for all the others).

    Code:
    MC1R loci	Anc/Der		DMXX
    rs1805007  	C/T		CC
    Y152OCH		C/A		--
    rs111400 	T/C		--
    rs1805009	G/C		--
    rs2228479 	G/A		GG
    N29insA 	C/A		--
    rs885479 	C/T		GG
    rs1805005 	G/T		GG
    rs11547464 	G/A		GG
    rs1805008	C/T		CC
    rs1805006	C/A		CC
    Phenotype			b,
    . No red beard hair
    b Some red beard hair
    B Predominantly red beard hair
    x n/a - for females!
    , No red head hair
    h Some red head hair
    H Predominantly red head hair
     

    Code:
    rs1805007(T) - Europe > South-Central Asia; absent elsewhere
    Y152OCH(A) - Absent everywhere
    rs111400(C) - Europe; absent elsewhere
    rs1805009(C) - Europe > East-Central Asia (Uyghurs); absent elsewhere
    rs2228479(A) - SE Asia > E Asia > Europe & South-Central Asia, absent elsewhere
    N29insA(A) - Europe (Orcadian only); absent elsewhere
    rs885479(T) - Americas + E Asia > South-Central Asia > Europe; absent elsewhere
    rs1805005(T) - Europe > Near-East > South-Central Asia > East-Central Asia + South Africa
    rs11547464(A) - Europe (Italy and North Russian only); absent elsewhere
    rs1805008(T) - Europe > East-Central Asia (Uyghur) > Near-East > South-Central Asia; absent elsewhere
    rs1805006(A) - Absent everywhere
    redhair3.jpgredhair4.jpgredhair2.jpgredhair1.jpg

  2. The Following 8 Users Say Thank You to DMXX For This Useful Post:

     AJL (01-31-2015),  dp (01-31-2015),  Jessie (05-02-2015),  khanabadoshi (08-03-2015),  rms2 (02-01-2015),  Stellaritic (05-01-2015),  surbakhunWeesste (01-31-2015),  Varun R (01-31-2015)

  3. #2
    Banned
    Posts
    1,280
    Sex
    Ethnicity
    Celt/German/Iberian
    Y-DNA (P)
    R1b-DF27
    mtDNA (M)
    U5b2a2b1

    Germany Imperial United Kingdom Norway Spain
    My phenotype. All my hair is red as far as I know. My father has the same red hair variants as me, but has dark brown hair.

    This is the only variant I have.

    rs1805008 C/T CT


    No call in N29insA and Y152OCH.
    Last edited by Krefter; 01-31-2015 at 12:59 AM.

  4. The Following 6 Users Say Thank You to Krefter For This Useful Post:

     DMXX (01-31-2015),  Jessie (05-02-2015),  khanabadoshi (08-03-2015),  rms2 (01-31-2015),  surbakhunWeesste (01-31-2015),  Varun R (01-31-2015)

  5. #3
    Registered Users
    Posts
    2,289
    Sex
    Location
    Canada
    Ethnicity
    Mixed Euro/Near East
    Nationality
    Canadian
    Y-DNA (P)
    R1a-YP4516/YP4807*
    mtDNA (M)
    H11a2a3

    Canada Franco-Manitoban European Union Ottoman Empire Russia Imperial United States Grand Union
    Two variants:

    rs1805007:CC
    rs2228479: GG
    rs885479: GG
    rs1805005: GT
    rs11547464: GG
    rs1805008:CT
    rs1805006: CC

    Predominantly red facial hair, slight red tinge to my hair when I was younger but it was more light brown than anything.
     

    Other ancestral Y lines:

    E1b-M81 Ukraine (Ashkenazi)
    E1b-V13 England
    I1-M253 Ireland
    I2-M423 Ukraine
    R1a-L176.1 Scotland
    R1b-L584 Syria/Turkey (Sephardi)
    R1b-L20 Ireland
    R1b-L21 (1)England; (2)Wales?>Connecticut
    R1b-L48 England
    R1b-P312 Scotland
    R1b-FGC32576 Ireland

    Other ancestral mtDNA lines:

    H1b2a Ukraine (Ashkenazi)
    H6a1a3 Ukraine
    K1a9 Belarus (Ashkenazi)
    K1c2 Ireland
    V7a Ukraine

  6. The Following 7 Users Say Thank You to AJL For This Useful Post:

     DMXX (01-31-2015),  Jessie (05-02-2015),  khanabadoshi (08-03-2015),  Krefter (01-31-2015),  rms2 (01-31-2015),  surbakhunWeesste (01-31-2015),  Varun R (01-31-2015)

  7. #4
    Banned
    Posts
    1,280
    Sex
    Ethnicity
    Celt/German/Iberian
    Y-DNA (P)
    R1b-DF27
    mtDNA (M)
    U5b2a2b1

    Germany Imperial United Kingdom Norway Spain
    Quote Originally Posted by AJL View Post
    Two variants:

    rs1805007:CC
    rs2228479: GG
    rs885479: GG
    rs1805005: GT
    rs11547464: GG
    rs1805008:CT
    rs1805006: CC

    Predominantly red facial hair, slight red tinge to my hair when I was younger but it was more light brown than anything.
    Do you get it from your Jewish side?

  8. The Following User Says Thank You to Krefter For This Useful Post:

     AJL (01-31-2015)

  9. #5
    Registered Users
    Posts
    935
    Sex
    Location
    N/A
    Ethnicity
    N/A
    Y-DNA (P)
    R2a (R-M124)
    mtDNA (M)
    U4b1a1a1

    Canada Jammu and Kashmir India
    Results identical to yours. I don't have any red hair.

    Code:
    MC1R loci	Anc/Der		bored
    rs1805007  	C/T		CC
    Y152OCH		C/A		--
    rs111400 	T/C		--
    rs1805009	G/C		--
    rs2228479 	G/A		GG
    N29insA 	C/A		--
    rs885479 	C/T		GG
    rs1805005 	G/T		GG
    rs11547464 	G/A		GG
    rs1805008	C/T		CC
    rs1805006	C/A		CC
    Last edited by bored; 01-31-2015 at 10:44 PM.

  10. The Following 4 Users Say Thank You to bored For This Useful Post:

     DMXX (01-31-2015),  kenji.aryan (01-31-2015),  rms2 (01-31-2015),  Varun R (01-31-2015)

  11. #6
    Gold Class Member
    Posts
    8,526

    All ancestral homozygous:
    rs1805007:CC
    rs2228479: GG
    rs885479: GG
    rs1805005: GG
    rs11547464: GG
    rs1805008: CC
    rs1805006: CC

  12. The Following 6 Users Say Thank You to parasar For This Useful Post:

     DMXX (01-31-2015),  Jessie (05-02-2015),  kenji.aryan (01-31-2015),  khanabadoshi (08-03-2015),  rms2 (01-31-2015),  Varun R (01-31-2015)

  13. #7
    Banned
    Posts
    368
    Sex
    Ethnicity
    Indo-aryan
    Y-DNA (P)
    J2b2*
    mtDNA (M)
    U7

    Scotland Canada India Ireland Russian Federation Albania
    Mine

    Positive at one variant


    Code:
    rs2228479 	G/A		AG






    Neanderthal Origin of the Haplotypes Carrying the Functional Variant Val92Met(rs2228479) in the MC1R in Modern Humans
    Abstract

    Skin color is one of the most visible and important phenotypes of modern humans. Melanocyte-stimulating hormone and its receptor played an important role in regulating skin color. In this paper, we present evidence of Neanderthal introgression encompassing the melanocyte-stimulating hormone receptor gene MC1R. The haplotypes from Neanderthal introgression diverged with the Altai Neanderthal 103.3 KYA, which postdates the anatomically modern human – Neanderthal divergence. We further discovered that all of the putative Neanderthal introgressive haplotypes carry the Val92Met variant, a loss-of-function variant in MC1R that is associated with multiple dermatological traits including skin color and photoaging. Frequency of this Neanderthal introgression is low in Europeans (~5%), moderate in continental East Asians (~30%), and high in Taiwanese aborigines (60-70%). Since the putative Neanderthal introgressive haplotypes carry a loss-of-function variant that could alter the function of MC1R and is associated with multiple traits related to skin color, we speculate that the Neanderthal introgression may have played an important role in the local adaptation of Eurasians to sunlight intensity.
    http://mbe.oxfordjournals.org/conten...su180.abstract


    SNpedia:


    "rs2228479, known as Val92Met or V92M, is one of several SNPs in the MC1R gene commonly associated with red (or blond) hair and poor tanning, but note its high presence in one Asian population [PMID 7581459, PMID 16463023]
    The risk allele is rs2228479(A), compared with the wild-type rs2228479(G) allele."
    http://www.snpedia.com/index.php/Rs2228479
    mc1r.jpg
    Last edited by kenji.aryan; 01-31-2015 at 07:16 AM.

  14. The Following 4 Users Say Thank You to kenji.aryan For This Useful Post:

     DMXX (01-31-2015),  Jessie (05-02-2015),  rms2 (02-01-2015),  Varun R (01-31-2015)

  15. #8
    Registered Users
    Posts
    2,289
    Sex
    Location
    Canada
    Ethnicity
    Mixed Euro/Near East
    Nationality
    Canadian
    Y-DNA (P)
    R1a-YP4516/YP4807*
    mtDNA (M)
    H11a2a3

    Canada Franco-Manitoban European Union Ottoman Empire Russia Imperial United States Grand Union
    Quote Originally Posted by Krefter View Post
    Do you get it from your Jewish side?
    No. This is one of the few genes I've been able to trace to a long-ago ancestor. It comes from a McLean, from the Scottish Highlands.
     

    Other ancestral Y lines:

    E1b-M81 Ukraine (Ashkenazi)
    E1b-V13 England
    I1-M253 Ireland
    I2-M423 Ukraine
    R1a-L176.1 Scotland
    R1b-L584 Syria/Turkey (Sephardi)
    R1b-L20 Ireland
    R1b-L21 (1)England; (2)Wales?>Connecticut
    R1b-L48 England
    R1b-P312 Scotland
    R1b-FGC32576 Ireland

    Other ancestral mtDNA lines:

    H1b2a Ukraine (Ashkenazi)
    H6a1a3 Ukraine
    K1a9 Belarus (Ashkenazi)
    K1c2 Ireland
    V7a Ukraine

  16. The Following 4 Users Say Thank You to AJL For This Useful Post:

     DMXX (01-31-2015),  Jessie (05-02-2015),  parasar (01-31-2015),  rms2 (01-31-2015)

  17. #9
    Registered Users
    Posts
    172
    Sex
    Omitted
    Location
    Midwest USA
    Ethnicity
    European
    Nationality
    USA
    Y-DNA (P)
    FGC5511*
    mtDNA (M)
    H9a

    Austria Hungary Ireland United States of America
    Some red head hair now

    rs1110400 TT
    rs2228479 AG
    rs885479 GG
    rs1805005 GG
    rs1805008 CC
    rs1805006 CC

    Maternal Grandmother Auburn Austrian
    Maternal Grandfather Redhead Magyar
    Paternal Grandmother Auburn County Tipperary
    390=21
    459a/b=9/9
    YCA II a/b=22/23
    557=15
    572=10
    RA1496 T+, RA1487 T+, DF23-, L1066-, L21+, M153-, M222-, M269+, M37-, M65-, P312+, P66-, SRY2627-, U106-, U152-, Z253-

  18. The Following 3 Users Say Thank You to slievenamon For This Useful Post:

     AJL (02-01-2015),  Jessie (05-02-2015),  rms2 (01-31-2015)

  19. #10
    Banned
    Posts
    13,888
    Sex
    Location
    Virginia, USA
    Ethnicity
    British and Irish
    Nationality
    USA
    Y-DNA (P)
    R1b-DF41>FGC36981
    mtDNA (M)
    U5a2c3a
    Y-DNA (M)
    R1b-Z253>BY93500
    mtDNA (P)
    K1a1a

    Wales Ireland Scotland France Bretagne England Switzerland
    I don't have results from 23andMe, but I have the following from FTDNA's Family Finder:

    rs1805008 C/T (also known as Arg160Trp and R160W)

    I got the same result from BritainsDNA's Red Head Test, as well, so it's confirmed by two independent sources.

    Red Head Test Result page BDNA.jpg Red hair Arg160Trp.png

    My dad also has CT at rs1805008 via Family Finder, and one of his older sisters, my Aunt Lois, had red hair. I'm currently waiting for my mom's Family Finder results.
    Last edited by rms2; 01-31-2015 at 10:40 PM. Reason: To add my dad's red hair variant result

  20. The Following 2 Users Say Thank You to rms2 For This Useful Post:

     DMXX (03-28-2015),  Jessie (05-02-2015)

Page 1 of 3 123 LastLast

Similar Threads

  1. Replies: 125
    Last Post: 02-20-2021, 11:21 AM
  2. 23andme raw data?
    By miarosie in forum 23andMe
    Replies: 0
    Last Post: 12-09-2019, 12:47 PM
  3. Replies: 5
    Last Post: 12-27-2018, 06:01 PM
  4. reading raw data genotype not determined
    By SlytherclawRavenpuff in forum 23andMe
    Replies: 0
    Last Post: 04-25-2018, 07:50 PM
  5. Replies: 13
    Last Post: 09-19-2017, 07:27 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •